This book comprehensively covers modern soft tissue pathology and includes both tumors and non-neoplastic entities. Soft tissues make up a large bulk of the human body, and they are susceptible to a wide range of diseases. Many soft-tissue tumors are biologically very aggressive, and the chance of them metastasizing to vital organs is quite high. In recent years, the outlook for soft-tissue cancers has brightened dramatically due to the increased accuracy of the pathologist’s tools. All methods of diagnosis are covered here, with an emphasis on the newest immunoassays and other genetic, molecular, and immunologic diagnostic modalities. This book’s systematic description of benign and malignant primary soft tissue tumors with didactic, comprehensive panels of illustrations allows the reader to formulate a complete understanding of the morphology of tumor entities at one glance. The book covers both the most common tumor entities and more unusual diseases using more than 1,500 color images, making it a resource for beginning and senior pathologists.

• Extensive panels of illustrations allow reader to quickly understand the histologic spectrum of tumors • Unique charts of tumor demography and anatomic location • Includes discussion of ancillary techniques • Expanded definition includes metastatic melanoma and carcinomas, etc.

Contents

1. Overview of soft tissue tumors Markku Miettinen; 2. Radiologic evaluation of soft tissue tumors Mark D. Murphey and Mark J. Kransdorf; 3. Immunohistochemistry of soft tissue tumors Markku Miettinen; 4. Genetics of soft tissue tumors Julia A. Bridge and Marilu Nelson; 5. Molecular genetics of soft tissue tumors Jerzy Lasota; 6. Fibroblast biology, fasciitis, retroperitoneal fibrosis, and keloid Markku Miettinen; 7. Fibromas and benign fibrous histiocytomas Markku Miettinen; 8. Fibromatoses Markku Miettinen; 9. Benign fibroblastic and myofibroblastic proliferations in children Markku Miettinen; 10. Childhood fibroblastic and myofibroblastic proliferations of variable biologic potential Markku Miettinen; 11. Myxomas and ossifying fibromyxoid tumor Markku Miettinen; 12. Solitary fibrous tumor, hemangiopericytoma, and related tumors Markku Miettinen; 13. Fibroblastic and myofibroblastic neoplasms with malignant potential Markku Miettinen; 14. Lipoma variants and conditions simulating lipomatous tumors Markku Miettinen; 15. Atypical lipomatous tumor and liposarcomas Markku Miettinen; 16. Smooth muscle tumors Markku Miettinen; 17. Gastrointestinal stromal tumor Markku Miettinen; 18. Stromal tumors and tumor-like lesions of the female genital tract Markku Miettinen; 19. Angiomyolipoma and related tumors (perivascular epithelioid cell tumors, PEComas) Markku Miettinen; 20. Rhabdomyomas and rhabdomyosarcomas Vinay Prasad, Kadria Sayed, Faridali Ramji, and David M. Parham; 21. Hemangiomas, lymphangiomas, and reactive vascular proliferations Markku Miettinen; 22. Hemangioendotheliomas, angiosarcomas, and Kaposi sarcoma Markku Miettinen; 23. Glomus tumor, sinonasal hemangiopericytoma, and myopericytoma Markku Miettinen; 24. Nerve sheath tumors Markku Miettinen; 25. Neuroectodermal tumors: melanocytic, glial, and meningeal neoplasms Markku Miettinen; 26. Paragangliomas Markku Miettinen; 27. Primary soft tumors with epithelial differentiation Markku Miettinen; 28. Malignant mesothelioma and other mesothelial proliferations Markku Miettinen; 29. Merkel cell carcinoma and metastatic and sarcomatoid carcinomas involving soft tissues Markku Miettinen; 30. Cartilage and bone-forming tumors and tumor-like lesions Julie C. Fanburg-Smith and Mark D. Murphey; 31. Small round cell tumors David M. Parham; 32. Alveolar soft part sarcoma Markku Miettinen; 33. Pathology of synovial and tendons Markku Miettinen; 34. Miscellaneous tumor-like lesions and histiocytic and foreign body reactions Markku Miettinen; 35. Lymphatic, myeloid, histiocytic, and dendritic cell proliferations in soft tissues Markku Miettinen; 36. Cytology of soft tissue lesions Matjaž Šebenik and Živa Pohar-Marinšek; 37. Surgical management of soft-tissue sarcoma: histiologic type and grade guides, surgical planning, and integration of multimodality therapy Charlotte Ariyan and Samuel Singer; 38. Medical oncology of soft tissue sarcomas Robert G. Maki.